The Gran Telescopio de Canarias (GTC) has recently added three new instruments to the already available instrumental offer. With a plethora of six optical and near‐infrared instruments operating over the past few years, astronomers from the three GTC communities, as well as others, are now materializing exciting science results out of GTC data. The main aim of this VI meeting on "Science with the GTC" is for participants to share their latest, interesting results, learn about GTC operations and the next generation instrumental proposals, encourage current collaborations and promote new collaborations between our GTC communities. The VI meeting on "Science with GTC" has been placed in Valencia, Spain, from the 12th to the 14th of December, 2018.